Signaling networks that convert graded stimuli into binary, all-or-none cellular responses are critical in processes ranging from cell-cycle control to lineage commitment.To exhaustively enumerate topologies that exhibit this switch-like behavior, we simulated all possible two- and three-component networks on random parameter sets, and assessed the
The most well-known Amazon stories exhibit a number of common characteristics, most notably their ultimate defeat at the hands of a legendary male hero.Even those narratives in which such characters did not achieve the same degree of renown as Heracles, Theseus or Achilles, as in the case of Bellerophon, or those who were not even granted puffy spa
Eucalyptus, valued for its rapid growth and economic potential, has been widely introduced in China to address timber demands while conserving natural forests.Precisely estimating the spatiotemporal expansion of short-rotation eucalyptus plantations is crucial for evaluating their ecological and social value and formulating effective sustainable fo
Global climate change has affected the rate of rising sea level, the frequency, intensity, timing, and distribution of hurricanes and tropical storms which threatens coastal ecosystems such as Bayou Perot, Little Lake in New Orleans along the Gulf of Mexico.The impact of hurricanes could include wetland and coastal land loss.This paper compared the